You won't like this answer, but there's absolutely no reason to use WinME, WinME was plagued with problems, use Win98 (if you can) instead. It's even possible some of the problems you complain about, interrupt assignment (IRQ), are probably related to WinME shortcomings and bugs.
If you want to keep using WinME I suggest you look for Win98 related posts and knowledge base articles to solve your issues.
Last edited by a moderator: Oct 3, 2013