parallels does not support the Safedisk technologies used by many game cds. This means you will get the error you are seeing. You can always try one of the many sites that will provide NOCD exes for games.... but its all a mute point given that Parallels doesnt support 3D graphics, so the game will more than likely fail to run anyway. You dont say what version of parallels you are using, so USB diagnosis is a little hard.
