I'm running ME3 in Win8. My problem is that my mouse leaves the game screen and will move to the second monitor if I go to far. It should leave the game screen at all. The other issue seems to be that looking around with the mouse stops if I get to the edge of the screen. It should be 360 all the time. I've tried windowed mode and full screen and it happens in both. Not sure what to do.
Try setting VM Configuration > Options > Advanced > SmartMouse to Off. Note this will lock mouse pointer in VM Window, press Ctrl+Alt to release it.
Smart Mouse was already off. I switched to Window mode instead of Coherence, and that seemed to do that trick.
